Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Identifieur interne : 000204 ( Main/Exploration ); précédent : 000203; suivant : 000205Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Auteurs : Renhong Yan [République populaire de Chine] ; Yuanyuan Zhang [République populaire de Chine] ; Yaning Li [République populaire de Chine] ; Lu Xia [République populaire de Chine] ; Yingying Guo [République populaire de Chine] ; Qiang Zhou [République populaire de Chine]Source :
- Science (New York, N.y.) [ 0036-8075 ] ; 2020.
Descripteurs français
- KwdFr :
- Alignement de séquences, Cryomicroscopie électronique, Domaines protéiques, Glycoprotéine de spicule des coronavirus (ultrastructure), Humains, Infections à coronavirus, Liaison aux protéines, Modèles moléculaires, Multimérisation de protéines, Pandémies, Peptidyl-Dipeptidase A (ultrastructure), Pneumopathie virale, Récepteurs viraux (ultrastructure), Systèmes de transport d'acides aminés neutres (ultrastructure), Séquence d'acides aminés, Virus du SRAS.
- MESH :
- ultrastructure : Glycoprotéine de spicule des coronavirus, Peptidyl-Dipeptidase A, Récepteurs viraux, Systèmes de transport d'acides aminés neutres.
- Alignement de séquences, Cryomicroscopie électronique, Domaines protéiques, Humains, Infections à coronavirus, Liaison aux protéines, Modèles moléculaires, Multimérisation de protéines, Pandémies, Pneumopathie virale, Séquence d'acides aminés, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Amino Acid Transport Systems, Neutral (ultrastructure), Betacoronavirus, Coronavirus Infections, Cryoelectron Microscopy, Humans, Models, Molecular, Pandemics, Peptidyl-Dipeptidase A (ultrastructure), Pneumonia, Viral, Protein Binding, Protein Domains, Protein Multimerization, Receptors, Virus (ultrastructure), SARS Virus, Sequence Alignment, Spike Glycoprotein, Coronavirus (ultrastructure).
- MESH :
- chemical , ultrastructure : Amino Acid Transport Systems, Neutral, Peptidyl-Dipeptidase A, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- Amino Acid Sequence, Betacoronavirus, Coronavirus Infections, Cryoelectron Microscopy, Humans, Models, Molecular, Pandemics, Pneumonia, Viral, Protein Binding, Protein Domains, Protein Multimerization, SARS Virus, Sequence Alignment.
Abstract
Scientists are racing to learn the secrets of severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease
COVID-19. The first step in viral entry is the binding of the viral trimeric spike protein
to the human receptor angiotensin-converting enzyme 2 (ACE2). Yan
Url:
DOI: 10.1126/science.abb2762
PubMed: 32132184
PubMed Central: 7164635
Affiliations:
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Le document en format XML
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ACE2</title><author><name sortKey="Yan, Renhong" sort="Yan, Renhong" uniqKey="Yan R" first="Renhong" last="Yan">Renhong Yan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yaning" sort="Li, Yaning" uniqKey="Li Y" first="Yaning" last="Li">Yaning Li</name><affiliation wicri:level="1"><nlm:aff id="aff3">Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xia, Lu" sort="Xia, Lu" uniqKey="Xia L" first="Lu" last="Xia">Lu Xia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yingying" sort="Guo, Yingying" uniqKey="Guo Y" first="Yingying" last="Guo">Yingying Guo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Qiang" sort="Zhou, Qiang" uniqKey="Zhou Q" first="Qiang" last="Zhou">Qiang Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author></analytic><series><title level="j">Science (New York, N.y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Amino Acid Transport Systems, Neutral (ultrastructure)</term><term>Betacoronavirus</term><term>Coronavirus Infections</term><term>Cryoelectron Microscopy</term><term>Humans</term><term>Models, Molecular</term><term>Pandemics</term><term>Peptidyl-Dipeptidase A (ultrastructure)</term><term>Pneumonia, Viral</term><term>Protein Binding</term><term>Protein Domains</term><term>Protein Multimerization</term><term>Receptors, Virus (ultrastructure)</term><term>SARS Virus</term><term>Sequence Alignment</term><term>Spike Glycoprotein, Coronavirus (ultrastructure)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Cryomicroscopie électronique</term><term>Domaines protéiques</term><term>Glycoprotéine de spicule des coronavirus (ultrastructure)</term><term>Humains</term><term>Infections à coronavirus</term><term>Liaison aux protéines</term><term>Modèles moléculaires</term><term>Multimérisation de protéines</term><term>Pandémies</term><term>Peptidyl-Dipeptidase A (ultrastructure)</term><term>Pneumopathie virale</term><term>Récepteurs viraux (ultrastructure)</term><term>Systèmes de transport d'acides aminés neutres (ultrastructure)</term><term>Séquence d'acides aminés</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="ultrastructure" xml:lang="en"><term>Amino Acid Transport Systems, Neutral</term><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term><term>Systèmes de transport d'acides aminés neutres</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Betacoronavirus</term><term>Coronavirus Infections</term><term>Cryoelectron Microscopy</term><term>Humans</term><term>Models, Molecular</term><term>Pandemics</term><term>Pneumonia, Viral</term><term>Protein Binding</term><term>Protein Domains</term><term>Protein Multimerization</term><term>SARS Virus</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Cryomicroscopie électronique</term><term>Domaines protéiques</term><term>Humains</term><term>Infections à coronavirus</term><term>Liaison aux protéines</term><term>Modèles moléculaires</term><term>Multimérisation de protéines</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Séquence d'acides aminés</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>How SARS-CoV-2 binds to human cells</title><p>Scientists are racing to learn the secrets of severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease
COVID-19. The first step in viral entry is the binding of the viral trimeric spike protein
to the human receptor angiotensin-converting enzyme 2 (ACE2). Yan <italic>et al.</italic>present the structure of human ACE2 in complex with a membrane protein that it chaperones,
B<sup>0</sup>AT1. In the context of this complex, ACE2 is a dimer. A further structure
shows how the receptor binding domain of SARS-CoV-2 interacts with ACE2 and suggests that
it is possible that two trimeric spike proteins bind to an ACE2 dimer. The structures
provide a basis for the development of therapeutics targeting this crucial
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G. Scott</name></author><author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K. Cowtan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yan, Renhong" sort="Yan, Renhong" uniqKey="Yan R" first="Renhong" last="Yan">Renhong Yan</name></noRegion><name sortKey="Guo, Yingying" sort="Guo, Yingying" uniqKey="Guo Y" first="Yingying" last="Guo">Yingying Guo</name><name sortKey="Guo, Yingying" sort="Guo, Yingying" uniqKey="Guo Y" first="Yingying" last="Guo">Yingying Guo</name><name sortKey="Li, Yaning" sort="Li, Yaning" uniqKey="Li Y" first="Yaning" last="Li">Yaning Li</name><name sortKey="Xia, Lu" sort="Xia, Lu" uniqKey="Xia L" first="Lu" last="Xia">Lu Xia</name><name sortKey="Xia, Lu" sort="Xia, Lu" uniqKey="Xia L" first="Lu" last="Xia">Lu Xia</name><name sortKey="Yan, Renhong" sort="Yan, Renhong" uniqKey="Yan R" first="Renhong" last="Yan">Renhong Yan</name><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><name sortKey="Zhou, Qiang" sort="Zhou, Qiang" uniqKey="Zhou Q" first="Qiang" last="Zhou">Qiang Zhou</name><name sortKey="Zhou, Qiang" sort="Zhou, Qiang" uniqKey="Zhou Q" first="Qiang" last="Zhou">Qiang Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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